2010 lineup
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- Muse
- Ozzy Osbourne
- My Morning Jacket
- Weezer
- MGMT
- Drake
- Metric
- Hot Chip
- Interpol
- Paul van Dyk
- deadmau5
- Street Sweeper Social Club
- Paul Oakenfold
- Jakob Dylan and Three Legs
- The Crystal Method DJ Set
- Ferry Corsten
- JP. Chrissie and The Fairground Boys
- Buckwheat Zydeco
- Florence And The Machine
- Macy Gray
- Kaskade
- Raphael Saadiq
- Eagles of Death Metal
- Cage the Elephant
- The Airborne Toxic Event
- Minus the Bear
- Galactic with special guests Cyril Neville and Corey Henry
- Dead Confederate
- Jonsi
- Janelle Monae
- Innerpartysystem
- Afrojack
- White Rabbits
- Die Antwoord
- Trombone Shorty & Orleans Avenue
- Eli “Paperboy” Reed & The True Loves
- Rebirth Brass Band
- Crookers
- The Whigs
- Boys Noize
- Preservation Hall Jazz Band
- MyNameIsJohnMichael
- Blackberry Smoke
- Stanton Moore Trio with Anders Osborne and Robert Walter
- Voice of the Wetlands All Stars
- Tab Benoit
- Cyril Neville
- Waylon Thibodeaux
- Big Chief Bourdeaux
- Johnny Vidacovich
- Johnny Sansone
- Soul Rebels Brass Band
- Theresa Andersson
- Jonathan Tyler and the Northern Lights
- Fitz & The Tantrums
- River City Extension
- Kermit Ruffins
- Dr. Michael White
- Jeremy Davenport
- Toubab Krewe
- Michael Tolcher
- Jon Cleary: Piano, Bass & Drums
- Swiss Chriss
- Treme Brass Band with Uncle Lionel Batiste
- O'Brother
- The Vettes
- Cedric Burnside & Lightnin Malcolm
- Big Sam's Funky Nation
- The New Orleans Bingo! Show
- Walter "Wolfman" Washington and The Roadmasters
- The Happy Talk Band
- Supagroup
- MarchFourth Marching Band
- Fleur de Tease Burlesque Revue
- Rotary Downs
- Rusko
- Paul Sanchez & the Rolling Road Show
- DJ Soul Sister
- Zydepunks
- Brian Coogan Band with Mike Dillon
- Quintron & Miss Pussycat
- Honey Island Swamp Band with Gal Holiday and the Soul Rebels Horns
- Kristin Diable
- Basin Street Records Revue
- Rosie Ledet
- Fatter Than Albert
- Leo Jackson and the Melody Clouds
- Trent Cantrelle
- AM
- Carmine P. Filthy
- Big Rock Candy Mountain
- Shannon McNally
- Electrocity
- Creole String Beans
- Beverly Skillz
- Blue Party feat. Natalie Mae
- Javier Drada
- Ponderosa
- Feufollet
- Christoph Andersson
- Rock City Morgue
- SPEAK
- Alvin Youngblood Hart's Muscle Theory
- Mia Borders
- Big Freedia, Katey Red, Sissy Nobby with DJ Rusty Lazer
- Locos Por Juana
- Johnny Sketch & the Dirty Notes
- Flow Tribe
- Consortium of Genius
- Luke Winslow-King
- Noisician Coalition
- DJ Quickie Mart
- Debauche
- Helen Gillet
- The Local Skank
- COOT
- MC Sweet Tea
- Egg Yolk Jubilee
- Rival Sons
- Miracle at St. Anna
- DJ T-Roy
- Como Mamas
- Blue Party feat. Natalie Mae
- Lost Bayou Ramblers
- Dex the Passion
